Abstract
Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CDK) activity and bypassing many of the processes of mitosis. Here we review the mechanisms of endoreplication, focusing on recent results from Drosophila and mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Cycle / physiology
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Cyclin E / metabolism
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Cyclin E / physiology
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Cyclin-Dependent Kinase 2 / metabolism
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Cyclin-Dependent Kinase 2 / physiology
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DNA Replication
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Drosophila / cytology
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Drosophila / genetics*
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Endoreduplication / physiology*
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Mice
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Polyploidy
Substances
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Cyclin E
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Cyclin-Dependent Kinase 2