Abstract
An up-to-date overview of thin-layer chromatography (TLC) techniques for chiral separations of various significant and/or recent examples of enantioresolutions is reported. Furthermore, examples for chiral separations obtained on achiral commercially available C18 TLC plates are described in detail. These include the enantioseparation of methylthiohydantoin-phenylalanine and methylthiohydantoin-tyrosine using hydroxyethyl-β-cyclodextrin as mobile phase additive and the separation of the enantiomers of warfarin and p-chlorowarfarin using bovine serum albumin as mobile phase additive.
MeSH terms
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Animals
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Cattle
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Cellulose / analysis
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Cellulose / chemistry
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Chromatography, Thin Layer / methods*
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Molecular Imprinting / methods
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Phenylalanine / analysis
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Phenylalanine / chemistry
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Polymers / analysis
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Polymers / chemistry
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Serum Albumin, Bovine / analysis
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Serum Albumin, Bovine / metabolism
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Thiohydantoins / analysis
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Thiohydantoins / chemistry
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Tyrosine / analysis
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Tyrosine / chemistry
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Warfarin / analysis
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Warfarin / chemistry
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beta-Cyclodextrins / analysis
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beta-Cyclodextrins / metabolism
Substances
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Polymers
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Thiohydantoins
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beta-Cyclodextrins
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Serum Albumin, Bovine
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Tyrosine
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Phenylalanine
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Warfarin
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methylthiohydantoin
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Cellulose