Abstract
Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Indonesia
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Inhibitory Concentration 50
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Mice
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Molecular Structure
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Naphthyridines / chemistry
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Naphthyridines / isolation & purification*
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Naphthyridines / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
Substances
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Antineoplastic Agents
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Naphthyridines
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aaptamine