16(th) IHIW: global analysis of registry HLA haplotypes from 20 million individuals: report from the IHIW Registry Diversity Group

M Maiers; L Gragert; A Madbouly; D Steiner; S G E Marsh; P-A Gourraud; M Oudshoorn; H van der Zanden; A H Schmidt; J Pingel; J Hofmann; C Müller; H-P Eberhard

doi:10.1111/iji.12031

16(th) IHIW: global analysis of registry HLA haplotypes from 20 million individuals: report from the IHIW Registry Diversity Group

Int J Immunogenet. 2013 Feb;40(1):66-71. doi: 10.1111/iji.12031. Epub 2012 Dec 26.

Authors

M Maiers¹, L Gragert, A Madbouly, D Steiner, S G E Marsh, P-A Gourraud, M Oudshoorn, H van der Zanden, A H Schmidt, J Pingel, J Hofmann, C Müller, H-P Eberhard

Affiliation

¹ Bioinformatics Research, National Marrow Donor Program (NMDP), Minneapolis, MN, USA. martinmaiers@gmail.com

Abstract

This project has the goal to validate bioinformatics methods and tools for HLA haplotype frequency analysis specifically addressing unique issues of haematopoietic stem cell registry data sets. In addition to generating new methods and tools for the analysis of registry data sets, the intent is to produce a comprehensive analysis of HLA data from 20 million donors from the Bone Marrow Donors Worldwide (BMDW) database. This report summarizes the activity on this project as of the 16IHIW meeting in Liverpool.

MeSH terms

Computational Biology
Gene Frequency
Genetic Variation*
HLA Antigens* / genetics
HLA Antigens* / immunology
Haplotypes* / genetics
Haplotypes* / immunology
Humans
Registries
Tissue Donors

Substances

HLA Antigens