Single Walled Carbon Nanotubes/polypyrrole-GOx composite films to modify gold microelectrodes for glucose biosensors: Study of the extended linearity

Biosens Bioelectron. 2013 May 15:43:75-8. doi: 10.1016/j.bios.2012.11.019. Epub 2012 Nov 30.

Abstract

A glucose biosensor was assembled using gold microelectrodes (diameter of 250 μm) coated by Single-Walled Carbon Nanotubes (SWCNTs), via the Electrophoresis Deposition Process (EPD). This nanostructured platform was successfully used to deposit the poly(pyrrole)/glucose oxidase film (PPy/GOx). The most important result of this biosensors was the wide linear range of concentration, ranging from 4 to100 mM (covering the hypo- and hyper-glycemia range, useful in diabetes). This extended linearity offered the possibility to measure glucose from 0.560 to 12.0 mM, with a detection limit of 50 μM (useful for hypo-glycemia disease).

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Conductometry / instrumentation*
  • Equipment Design
  • Equipment Failure Analysis
  • Glucose / analysis*
  • Glucose / chemistry
  • Glucose Oxidase / chemistry*
  • Gold / chemistry
  • Graphite / chemistry
  • Linear Models
  • Microelectrodes*
  • Nanotubes, Carbon / chemistry*
  • Oxides / chemistry
  • Polymers / chemistry*
  • Pyrroles / chemistry*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Nanotubes, Carbon
  • Oxides
  • Polymers
  • Pyrroles
  • polypyrrole
  • Gold
  • Graphite
  • Glucose Oxidase
  • Glucose