New sesquiterpenes and phenolic compound from Ficus foveolata

Abstract

Two new eudesmane-type sesquiterpenes, named foveolide A (1) and foveoeudesmenone (2), one new sesquiterpenoid dimer, foveolide B (3) and a new phenolic compound, foveospirolide (4), were isolated along with six known compounds, including 4(15)-eudesmene-1β, 6α-diol (5), 4(15)-eudesmene-1β, 5α-diol (6), friedelin, taraxerol, betulin and ethyl rosmarinate, from the stems of Ficus foveolata. The structures of these new compounds were characterized by spectroscopic methods (IR, MS and NMR). Compound 1 exhibited moderate cytotoxicity against SW620, HepG2, BT474 and KATO-III cancer cell lines, whereas compound 3 was specifically cytotoxic toward SW620 cell line.