Abstract
Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Bacterial Typing Techniques
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Cattle
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Genetic Loci
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Genome, Bacterial*
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Humans
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Methicillin Resistance / drug effects
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Methicillin-Resistant Staphylococcus aureus / genetics*
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Penicillin-Binding Proteins
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Protein Isoforms / genetics
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Staphylococcus / drug effects
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Staphylococcus / genetics*
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Staphylococcus / isolation & purification*
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Transcription Factors / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Penicillin-Binding Proteins
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Protein Isoforms
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SarH1 protein, Staphylococcus aureus
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Transcription Factors
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mecA protein, Staphylococcus aureus