Case-control association study of 36 single-nucleotide polymorphisms within 10 candidate genes for major depression and bipolar disorder

Concetta Crisafulli; Alberto Chiesa; Changsu Han; Soo-Jung Lee; Beatrice Balzarro; Costanza Andrisano; Antonina Sidoti; Ashwin A Patkar; Chi-Un Pae; Alessandro Serretti

doi:10.1016/j.psychres.2012.11.009

Case-control association study of 36 single-nucleotide polymorphisms within 10 candidate genes for major depression and bipolar disorder

Psychiatry Res. 2013 Aug 30;209(1):121-3. doi: 10.1016/j.psychres.2012.11.009. Epub 2012 Dec 27.

Authors

Concetta Crisafulli¹, Alberto Chiesa, Changsu Han, Soo-Jung Lee, Beatrice Balzarro, Costanza Andrisano, Antonina Sidoti, Ashwin A Patkar, Chi-Un Pae, Alessandro Serretti

Affiliation

¹ Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Messina, Italy.

PMID: 23273899
DOI: 10.1016/j.psychres.2012.11.009

Abstract

In this study we investigated 36 single nucleotide polymorphisms within 10 genes previously associated with major depression and bipolar disorder, as well as with the response to their treatment (ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2). No association with mood disorders and clinical outcomes was observed.

Keywords: Bipolar disorder; Major depression; Single nucleotide polymorphisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Depressive Disorder, Major / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Male
Polymorphism, Single Nucleotide / genetics*
Psychiatric Status Rating Scales