Abstract
We have developed a nickel-catalyzed cross coupling of benzylic ammonium triflates with aryl boronic acids to afford diarylmethanes and diarylethanes. This reaction proceeds under mild reaction conditions and with exceptional functional group tolerance. Further, it transforms branched benzylic ammonium salts to diarylethanes with excellent chirality transfer, offering a new strategy for the synthesis of highly enantioenriched diarylethanes from readily available chiral benzylic amines.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Boronic Acids / chemistry*
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Catalysis
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Crystallography, X-Ray
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Ethane / analogs & derivatives
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Ethane / chemical synthesis*
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Ethane / chemistry
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Models, Molecular
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Molecular Conformation
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Nickel / chemistry*
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Organometallic Compounds / chemistry*
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Quaternary Ammonium Compounds / chemistry*
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Salts / chemistry
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Stereoisomerism
Substances
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Boronic Acids
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Organometallic Compounds
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Quaternary Ammonium Compounds
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Salts
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Nickel
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Ethane