Cytosporone S with antimicrobial activity, isolated from the fungus Trichoderma sp. FKI-6626

Takahiro Ishii; Kenichi Nonaka; Takuya Suga; Rokuro Masuma; Satoshi Ōmura; Kazuro Shiomi

doi:10.1016/j.bmcl.2012.11.113

Cytosporone S with antimicrobial activity, isolated from the fungus Trichoderma sp. FKI-6626

Bioorg Med Chem Lett. 2013 Feb 1;23(3):679-81. doi: 10.1016/j.bmcl.2012.11.113. Epub 2012 Dec 3.

Authors

Takahiro Ishii¹, Kenichi Nonaka, Takuya Suga, Rokuro Masuma, Satoshi Ōmura, Kazuro Shiomi

Affiliation

¹ Kitasato Institute for Life Sciences, Kitasato University, Tokyo 108-8641, Japan.

PMID: 23265882
DOI: 10.1016/j.bmcl.2012.11.113

Abstract

A new microbial metabolite, cytosporone S (1) was isolated from a fermentation broth of the fungus Trichoderma sp. FKI-6626. Its chemical structure was determined primarily by NMR spectroscopy and mass spectrometry. Compound 1 showed antimicrobial activity against several Gram-positive and Gram-negative bacteria and fungi.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology*
Bacteria / drug effects*
Benzopyrans / chemistry
Benzopyrans / isolation & purification*
Benzopyrans / pharmacology*
Fungi / drug effects*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Trichoderma / chemistry*

Substances

Anti-Bacterial Agents
Antifungal Agents
Benzopyrans
cytosporone S