Surveillance of macrolide-resistant Mycoplasma pneumoniae in Beijing, China, from 2008 to 2012

Antimicrob Agents Chemother. 2013 Mar;57(3):1521-3. doi: 10.1128/AAC.02060-12. Epub 2012 Dec 21.

Abstract

Macrolide resistance rates of Mycoplasma pneumoniae in the Beijing population were as high as 68.9%, 90.0%, 98.4%, 95.4%, and 97.0% in the years 2008 to 2012, respectively. Common macrolide-resistant mobile genetic elements were not detected with any isolate. These macrolide-resistant isolates came from multiple clones rather than the same clone. No massive aggregation of a particular clone was found in a specific period.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • China
  • Clone Cells
  • Drug Resistance, Bacterial / drug effects*
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Minisatellite Repeats
  • Mutation
  • Mycoplasma pneumoniae / drug effects*
  • Mycoplasma pneumoniae / genetics*
  • Mycoplasma pneumoniae / isolation & purification
  • Pneumonia, Mycoplasma / drug therapy*
  • Pneumonia, Mycoplasma / microbiology
  • Public Health Surveillance
  • RNA, Ribosomal, 23S / genetics*
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • RNA, Ribosomal, 23S