This study examines an analog circuit comprising a multilayer perceptron neural network (MLPNN). This study proposes a low-power and small-area analog MLP circuit to implement in an E-nose as a classifier, such that the E-nose would be relatively small, power-efficient, and portable. The analog MLP circuit had only four input neurons, four hidden neurons, and one output neuron. The circuit was designed and fabricated using a 0.18 μm standard CMOS process with a 1.8 V supply. The power consumption was 0.553 mW, and the area was approximately 1.36 × 1.36 mm2. The chip measurements showed that this MLPNN successfully identified the fruit odors of bananas, lemons, and lychees with 91.7% accuracy.