NO inhibitory guaianolide-derived terpenoids from Artemisia argyi

Fitoterapia. 2013 Mar:85:169-75. doi: 10.1016/j.fitote.2012.12.005. Epub 2012 Dec 20.

Abstract

An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Artemisia / chemistry*
  • Cell Line
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Plant Leaves / chemistry
  • Sesterterpenes / chemistry
  • Sesterterpenes / isolation & purification*
  • Sesterterpenes / pharmacology

Substances

  • Lactones
  • Sesterterpenes
  • isoartemisolide
  • Nitric Oxide