Investigation of the human anterior segment in normal Chinese subjects using a dual Scheimpflug analyzer

Abstract

Purpose: To investigate anterior segment parameters in normal Chinese subjects and study factors influencing these parameters, such as age, gender, and laterality.

Design: A prospective observational case series.

Participants: A total of 291 normal subjects (582 eyes) were included.

Methods: The anterior segment data were determined with a dual Scheimpflug analyzer.

Main outcome measures: The corneal thinnest-point thickness (CTPT), corneal thinnest-point distribution (CTPD), central corneal thickness (CCT), corneal thickness (CT) in the central 10 mm diameter, pupil diameter (PD), pupil center distribution (PCD), anterior chamber depth (ACD), and anterior chamber volume (ACV, 8-mm diameter) were measured.

Results: The mean distance between the thinnest point and the corneal vertex was 0.70 ± 0.32 mm in the right eyes and 0.42 ± 0.25 mm in the left eyes; the thinnest point was located in the inferior temporal region in 71.1% of the right eyes and 55% of the left eyes. The CCT values were thicker than the CTPT values, and they were positively correlated (right eyes r = 0.994, P<0.001; left eyes r = 0.997, P<0.001). The distance between the pupillary center and the corneal vertex was approximately 0.39 ± 0.27 mm in the right eyes and 0.37 ± 0.24 mm in the left eyes. Furthermore, the percentage of pupillary centers located in the superior regions was 72.2% in the right eyes and 73.5% in the left eyes. Age was negatively correlated with the peripheral CT (7-10 mm diameter), PD, ACD, and ACV of both eyes and the mid-peripheral CT (4-7 mm diameter) of the right eye. Laterality correlated with CTPT (P<0.001) and PD (P<0.001), whereas gender correlated with ACD (P<0.001) and ACV (P = 0.009).

Conclusions: The majority of the thinnest corneal points were located in the inferior temporal quadrant, and the pupillary center was located in the superior region of the cornea; both differed substantially from the corneal vertex. The CT increased gradually from the center to the periphery. Age, gender, and laterality correlated with some indexes.