Blending hippo and WNT: sharing messengers and regulation

Becky P Tsai; Nate P Hoverter; Marian L Waterman

doi:10.1016/j.cell.2012.12.007

Blending hippo and WNT: sharing messengers and regulation

Cell. 2012 Dec 21;151(7):1401-3. doi: 10.1016/j.cell.2012.12.007.

Authors

Becky P Tsai¹, Nate P Hoverter, Marian L Waterman

Affiliation

¹ Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.

PMID: 23260132
DOI: 10.1016/j.cell.2012.12.007

Abstract

Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin et al. show how the Hippo transcription factor TAZ mediates Wnt signals, and Rosenbluh et al. show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.

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