Chromogenic and fluorogenic sensing of biological thiols in aqueous solutions using BODIPY-based reagents

Murat Isik; Tugba Ozdemir; Ilke Simsek Turan; Safacan Kolemen; Engin U Akkaya

doi:10.1021/ol303306s

Chromogenic and fluorogenic sensing of biological thiols in aqueous solutions using BODIPY-based reagents

Org Lett. 2013 Jan 4;15(1):216-9. doi: 10.1021/ol303306s. Epub 2012 Dec 20.

Authors

Murat Isik¹, Tugba Ozdemir, Ilke Simsek Turan, Safacan Kolemen, Engin U Akkaya

Affiliation

¹ UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.

PMID: 23256788
DOI: 10.1021/ol303306s

Abstract

Judicious design of BODIPY dyes carrying nitroethenyl substituents in conjugation with the BODIPY core yields dyes that respond to biological thiols by both absorbance and emission changes. Incorporation of solubilizing ethyleneglycol units ensures water solubility. The result is bright signaling of biologically relevant thiols in the longer wavelength region of the visible spectrum and in aqueous solutions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds / chemical synthesis*
Boron Compounds / chemistry
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry
Indicators and Reagents
Molecular Structure
Solutions
Sulfhydryl Compounds / analysis*
Water / chemistry

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Fluorescent Dyes
Indicators and Reagents
Solutions
Sulfhydryl Compounds
Water