Abstract
We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antitubercular Agents / pharmacology*
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Copper / pharmacology*
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Drug Design
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High-Throughput Screening Assays / methods*
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / pathogenicity
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Phenanthrolines / pharmacology
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Trace Elements / pharmacology
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Tuberculosis
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Virulence Factors
Substances
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Antitubercular Agents
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Phenanthrolines
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Trace Elements
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Virulence Factors
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Copper
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neocuproine
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bathocuproine