Abstract
Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry
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Abietanes / isolation & purification
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Abietanes / pharmacology
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cell Line, Tumor
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China
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Circular Dichroism
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Humans
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Illicium / chemistry*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neutrophils / drug effects
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Organometallic Compounds
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Plants, Medicinal
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Rats
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Stereoisomerism
Substances
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Abietanes
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Anti-Inflammatory Agents
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Diterpenes
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Organometallic Compounds
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Sesquiterpenes
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dimolybdenum tetraacetate