A novel multifunctional nano-platform with enhanced anti-cancer and photoacoustic imaging modalities using gold-nanorod-filled silica nanobeads

Chem Commun (Camb). 2013 Jan 30;49(9):892-4. doi: 10.1039/c2cc37702k.

Abstract

The novel nano-seaurchin structure is characteristic of high-density and well-dispersed gold nanorods in one mesoporous silica nanobead. This nanoplatform provided increased photothermal stability, stable photoacoustic signal and highly efficient hyperthermia effect both in vitro and in vivo, indicating a powerful theranostic modality.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Gold / chemistry
  • Gold / therapeutic use*
  • Humans
  • Hyperthermia, Induced / methods
  • Mice
  • Mice, Nude
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Neoplasms / diagnosis
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Phototherapy / methods
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / therapeutic use*
  • Ultrasonography

Substances

  • Gold
  • Silicon Dioxide