Immunocytochemistry as an adjunct to diagnostic cytology
Ann Pathol. 2012 Dec;32(6):e47-51, 433-7.
doi: 10.1016/j.annpat.2012.09.205.
Epub 2012 Nov 20.
[Article in
English,
French]
Affiliation
- 1 Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Manitoba, Hôpital Général de Saint Boniface, 409, avenue Taché, Winnipeg, Manitoba, Canada R2H 2A6. mpdupre@gmail.com
Abstract
Immunocytochemistry as a routine ancillary test remains a distant reality for most diagnostic laboratories. Notable barriers to the mass deployment of ICC include: the large variety of specimen preparations, the small specimen size, lack of validation and lack of control specimens. As clinicians constantly strive to answer questions relating to diagnosis, therapy and prognosis with minimally invasive sampling techniques, the cytopathology community must endeavour to adopt ancillary specimen testing by ICC as a core element of diagnostic cytology.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Antibody Specificity
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Automation
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Biopsy, Fine-Needle
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Body Fluids / cytology
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Centrifugation
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Cytodiagnosis* / trends
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Dose-Response Relationship, Immunologic
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Humans
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Immunohistochemistry* / methods
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Immunohistochemistry* / standards
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Immunohistochemistry* / trends
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Microtomy
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Neoplasms / pathology
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Paraffin Embedding
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Reference Standards
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Specimen Handling
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Staining and Labeling