Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate

Yi Kou; Young Cheun; Myong Chul Koag; Seongmin Lee

doi:10.1016/j.steroids.2012.10.021

Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate

Steroids. 2013 Feb;78(2):304-11. doi: 10.1016/j.steroids.2012.10.021. Epub 2012 Dec 10.

Authors

Yi Kou¹, Young Cheun, Myong Chul Koag, Seongmin Lee

Affiliation

¹ The Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA.

PMID: 23238516
DOI: 10.1016/j.steroids.2012.10.021

Abstract

An analog of ritterazine Y was synthesized from hecogenin acetate in 23 steps via functional group manipulations of hecogenin acetate. Preparation of the north G and south Y units and the late stage Guo-Fuchs asymmetric coupling of the both units afforded the ritterazine Y analog.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Magnetic Resonance Spectroscopy
Oxidation-Reduction
Phenazines / chemical synthesis*
Phenazines / chemistry
Spiro Compounds / chemical synthesis*
Spiro Compounds / chemistry
Steroids / chemical synthesis*
Steroids / chemistry

Substances

Antineoplastic Agents
Phenazines
Spiro Compounds
Steroids
hecogenin acetate