The theory of herbal properties of traditional Chinese medicine (TCM) is an indispensable part of theoretical system of TCM and plays an important role in the clinical prescription and application of TCM. In this theoretical system, the theory of four herbal properties takes a core and dominant position and becomes an indispensable part of TCM natures and actions. In combination of studies and experience, this essay proposes the latest discovery in modern biology-modern scientific connotation of cold and hot herbal properties on the basis of cold and hot perceptions of organism on the basis of analysis and summary of TRP channel protein and correlation of cold and hot perceptions of organism and thermoregulation, which is an effective approach to make breakthroughs in studies on modernization drive of the theory of four herbal properties of TCM.