Copper-catalyzed C-N bond formation through C-H/N-H activation: a novel approach to the synthesis of multisubstituted ureas

Chem Commun (Camb). 2013 Jan 28;49(8):819-21. doi: 10.1039/c2cc36417d.

Abstract

A copper-catalyzed cross-dehydrogenative coupling reaction that involves C-H activation of formamides and N-H activation of N-alkoxy amides has been developed. This protocol affords a novel approach to the synthesis of multisubstituted ureas under mild conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis
  • Amides / chemistry*
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Copper / chemistry*
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis

Substances

  • Amides
  • Copper
  • Urea