We present the case of a 39-year-old woman with autosomal dominant polycystic kidney disease (ADPKD). She was admitted to our hospital with marked dyspnea and epigastric pain. A diagnosis of giant hepatic cyst compressing the surrounding organs was made on the basis of the clinical and radiological findings. The patient underwent percutaneous aspiration of the cyst. The symptoms and radiological abnormalities were normalized within a few days of the minimally invasive aspiration procedure.