Plasmid content of a clinically relevant Klebsiella pneumoniae clone from the Czech Republic producing CTX-M-15 and QnrB1

Monika Dolejska; Laura Villa; Hana Dobiasova; Daniela Fortini; Claudia Feudi; Alessandra Carattoli

doi:10.1128/AAC.01886-12

Plasmid content of a clinically relevant Klebsiella pneumoniae clone from the Czech Republic producing CTX-M-15 and QnrB1

Antimicrob Agents Chemother. 2013 Feb;57(2):1073-6. doi: 10.1128/AAC.01886-12. Epub 2012 Dec 10.

Authors

Monika Dolejska¹, Laura Villa, Hana Dobiasova, Daniela Fortini, Claudia Feudi, Alessandra Carattoli

Affiliation

¹ Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.

Abstract

The entire plasmid content of a multidrug-resistant, CTX-M-15-producing Klebsiella pneumoniae ST416 clone was investigated. Two FII(K) plasmids, pKDO1 (127 kb) and pKPN-CZ (207 kb), were identified and found to carry a formidable set of genes conferring resistance to toxic compounds, metals, and antimicrobial drugs and exhibiting novel features putatively associated with adaptation and fitness of the bacterium in the human host.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology
Bacterial Proteins / biosynthesis
Bacterial Proteins / metabolism*
Czech Republic
Drug Resistance, Multiple, Bacterial / genetics
Klebsiella Infections / drug therapy
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics*
Metals / pharmacology
Microbial Sensitivity Tests
Molecular Sequence Data
Plasmids / genetics*
beta-Lactamases / biosynthesis
beta-Lactamases / metabolism*

Substances

Anti-Infective Agents
Bacterial Proteins
Metals
Qnr protein, Klebsiella pneumoniae
beta-lactamase CTX-M-15
beta-Lactamases

Associated data

GENBANK/JX424423
GENBANK/JX424424