Carbazoles via AuCl3-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols

Org Lett. 2012 Dec 21;14(24):6198-201. doi: 10.1021/ol3029498. Epub 2012 Dec 10.

Abstract

AuCl(3)-catalyzed reaction of 1-(indol-2-yl)-3-alkyn-1-ols occurred smoothly in toluene at room temperature to form a benzene ring leading to a series of carbazole derivatives efficiently. A possible mechanism has been proposed for the formation of carbazoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbazoles / chemical synthesis*
  • Carbazoles / chemistry
  • Catalysis
  • Cyclization
  • Indoles / chemistry*
  • Molecular Structure

Substances

  • Alkynes
  • Carbazoles
  • Indoles