PEM anchorage on titanium using catechol grafting

PLoS One. 2012;7(11):e50326. doi: 10.1371/journal.pone.0050326. Epub 2012 Nov 30.

Abstract

Background: This study deals with the anchorage of polyelectrolyte films onto titanium surfaces via a cathecol-based linker for biomedical applications.

Methodology: The following study uses a molecule functionalized with a catechol and a carboxylic acid: 3-(3,4-dihydroxyphenyl)propanoic acid. This molecule is anchored to the TiO(2) substrate via the catechol while the carboxylic acid reacts with polymers bearing amine groups. By providing a film anchorage of chemisorption type, it makes possible to deposit polyelectrolytes on the surface of titanium.

Principal findings: Infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), contact angle and atomic force microscopy (AFM) measurements show that the different steps of grafting have been successfully performed.

Conclusions: This method based on catechol anchorage of polyelectrolytes open a window towards large possibilities of clinical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catechols / chemistry*
  • Coated Materials, Biocompatible / chemical synthesis*
  • Electrolytes / chemistry*
  • Microscopy, Atomic Force
  • Phenylpropionates / chemistry*
  • Photoelectron Spectroscopy
  • Polymers / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • Titanium / chemistry*

Substances

  • Catechols
  • Coated Materials, Biocompatible
  • Electrolytes
  • Phenylpropionates
  • Polymers
  • Titanium
  • catechol

Grants and funding

Funding: PEPS-ST2I 2009. Projets exploratoires : Collaboration avec Mme Bérangère TOURY du Laboratoire des Multimatériaux et Interfaces (LMI) de Villeurbanne, UMR 5615 CNRS. « Revêtements de fonctionnalisation antiseptique pour dispositifs médicaux odontologiques. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.