Non-enzymatic dynamic kinetic resolution of secondary aryl alcohols: planar chiral ferrocene and ruthenium catalysts in cooperation

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):502-4. doi: 10.1002/anie.201207648. Epub 2012 Dec 6.

Abstract

"Ruth" helps iron! A novel method for the non-enzymatic dynamic kinetic resolution (DKR) of secondary aryl alcohols by the use of the planar chiral ferrocene derivative (+)-1 in combination with the ruthenium racemization catalyst 2 yields acetylated alcohols in high enantioselectivity and yield. This development opens opportunities for new developments in the field of non-enzymatic dynamic kinetic resolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Alcohols / chemistry*
  • Catalysis
  • Ferrous Compounds / chemical synthesis
  • Ferrous Compounds / chemistry*
  • Kinetics
  • Metallocenes
  • Molecular Dynamics Simulation
  • Molecular Structure
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Alcohols
  • Ferrous Compounds
  • Metallocenes
  • Ruthenium
  • ferrocene