Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: natural thioether Michael addition adducts as antitubercular prodrugs

Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1231-4. doi: 10.1002/anie.201208801. Epub 2012 Dec 6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / isolation & purification
  • Antitubercular Agents / pharmacology
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology
  • China
  • Geologic Sediments / microbiology*
  • Micromonosporaceae / chemistry*
  • Mycobacterium bovis / drug effects
  • Mycobacterium tuberculosis / drug effects
  • Oxidation-Reduction
  • Prodrugs / chemistry*
  • Prodrugs / isolation & purification
  • Prodrugs / pharmacology
  • Sulfides / chemistry*

Substances

  • Antitubercular Agents
  • Bridged Bicyclo Compounds, Heterocyclic
  • Prodrugs
  • Sulfides
  • abyssomicin J
  • abyssomicin K
  • abyssomicin L