Abstract
Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / metabolism*
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Endoplasmic Reticulum / chemistry
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Endoplasmic Reticulum / metabolism
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Endoplasmic Reticulum / physiology*
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Humans
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Inositol 1,4,5-Trisphosphate Receptors / metabolism*
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Ryanodine Receptor Calcium Release Channel / metabolism*
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Sarcoplasmic Reticulum / chemistry
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Sarcoplasmic Reticulum / metabolism
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Sarcoplasmic Reticulum / physiology*
Substances
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Calcium Channels
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Inositol 1,4,5-Trisphosphate Receptors
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Ryanodine Receptor Calcium Release Channel
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Calcium