Themes and variations in ER/SR calcium release channels: structure and function

Physiology (Bethesda). 2012 Dec;27(6):331-42. doi: 10.1152/physiol.00013.2012.

Abstract

Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism*
  • Endoplasmic Reticulum / chemistry
  • Endoplasmic Reticulum / metabolism
  • Endoplasmic Reticulum / physiology*
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / metabolism*
  • Ryanodine Receptor Calcium Release Channel / metabolism*
  • Sarcoplasmic Reticulum / chemistry
  • Sarcoplasmic Reticulum / metabolism
  • Sarcoplasmic Reticulum / physiology*

Substances

  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate Receptors
  • Ryanodine Receptor Calcium Release Channel
  • Calcium