Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin-β-carboline conjugate

Chem Commun (Camb). 2013 Jan 25;49(7):683-5. doi: 10.1039/c2cc38018h.

Abstract

Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin-β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC(50) = 60 nM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Carbolines / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Lung Neoplasms / drug therapy
  • Metalloporphyrins / chemical synthesis
  • Metalloporphyrins / pharmacology*
  • Photochemotherapy
  • Porphyrins / pharmacology*
  • Triazoles / pharmacology
  • Zinc / chemistry*

Substances

  • Antineoplastic Agents
  • Carbolines
  • Metalloporphyrins
  • Porphyrins
  • Triazoles
  • Zinc