Abstract
Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin-β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC(50) = 60 nM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Carbolines / pharmacology*
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Cell Line, Tumor
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Humans
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Lung Neoplasms / drug therapy
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Metalloporphyrins / chemical synthesis
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Metalloporphyrins / pharmacology*
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Photochemotherapy
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Porphyrins / pharmacology*
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Triazoles / pharmacology
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Zinc / chemistry*
Substances
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Antineoplastic Agents
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Carbolines
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Metalloporphyrins
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Porphyrins
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Triazoles
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Zinc