Abstract
Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid / chemistry
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Antioxidants* / chemical synthesis
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Antioxidants* / chemistry
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Benzoic Acid / chemistry
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Caffeic Acids* / chemical synthesis
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Caffeic Acids* / chemistry
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Carbon / chemistry
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Lipid Peroxidation
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Oxidation-Reduction
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Phenylethyl Alcohol / analogs & derivatives*
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Phenylethyl Alcohol / chemical synthesis
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Phenylethyl Alcohol / chemistry
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Propionates / chemistry
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Propolis / chemistry*
Substances
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Antioxidants
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Caffeic Acids
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Propionates
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Carbon
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Benzoic Acid
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Propolis
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caffeic acid phenethyl ester
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propionic acid
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Phenylethyl Alcohol
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Acetic Acid