In silico search of DNA drugs targeting oncogenes

IEEE/ACM Trans Comput Biol Bioinform. 2012 Nov-Dec;9(6):1826-30. doi: 10.1109/TCBB.2012.127.

Abstract

Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Base Sequence
  • Computer Simulation
  • DNA / chemistry*
  • DNA / metabolism
  • Drug Discovery / methods*
  • Gene Targeting / methods*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Molecular Targeted Therapy
  • Nucleic Acid Conformation
  • Oligonucleotides / chemistry
  • Oncogenes / drug effects*
  • RNA, Messenger / genetics
  • Sequence Analysis, DNA / methods*
  • Transcription, Genetic

Substances

  • Antineoplastic Agents
  • Oligonucleotides
  • RNA, Messenger
  • DNA