Recurrences in tuberculosis in a cohort of human immunodeficiency virus-infected patients: the influence of highly active antiretroviral therapy

Enferm Infecc Microbiol Clin. 2013 Apr;31(4):227-9. doi: 10.1016/j.eimc.2012.08.008. Epub 2012 Dec 6.

Abstract

Background: Little is known about recurrent tuberculosis (TB) among HIV-infected patients and the influence of highly active antiretroviral therapy (HAART).

Methods: A population-based retrospective longitudinal study was conducted on all HIV-infected TB patients in Barcelona (Spain) notified in 1987-2003, and followed up until 2005. TB recurrence and HAART influence were analysed according to calendar period.

Results: Patients with no-treatment and those in pre-HAART had more risk of TB recurrence (RR: 2.3; CI: 1-5.8 and RR: 4.8; CI: 2-12).

Conclusions: HAART decreases probability of TB recurrence and should be extended to all cases.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active*
  • Comorbidity
  • Female
  • Follow-Up Studies
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology*
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Recurrence
  • Registries
  • Retrospective Studies
  • Risk
  • Spain / epidemiology
  • Tuberculosis / epidemiology*
  • Young Adult

Substances

  • Anti-HIV Agents