IAP proteins: regulators of cell migration and development

Niall S Kenneth; Colin S Duckett

doi:10.1016/j.ceb.2012.11.004

IAP proteins: regulators of cell migration and development

Curr Opin Cell Biol. 2012 Dec;24(6):871-5. doi: 10.1016/j.ceb.2012.11.004. Epub 2012 Dec 5.

Authors

Niall S Kenneth¹, Colin S Duckett

Affiliation

¹ Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA.

PMID: 23219152
DOI: 10.1016/j.ceb.2012.11.004

Abstract

The cytoprotective properties of vertebrate inhibitor of apoptosis (IAP) proteins have been the subject of much study. These proteins have, however, emerged as key signaling intermediates modulating a variety of cellular functions through their ability to act as E3 ubiquitin ligases. This review will focus on the cell death-independent roles of the IAP proteins, focusing on recent reports indicating that c-IAPs and XIAP are key molecules involved in modulating cell migration and development.

Publication types

Review

MeSH terms

Animals
Apoptosis
Cell Movement*
Growth and Development
Humans
Inhibitor of Apoptosis Proteins / metabolism*
Ubiquitin-Protein Ligases / metabolism
Wnt Signaling Pathway

Substances

Inhibitor of Apoptosis Proteins
Ubiquitin-Protein Ligases