Nuclear transport: beginning to gel?

Curr Biol. 2012 Dec 4;22(23):R1006-9. doi: 10.1016/j.cub.2012.10.037.

Abstract

The massive nuclear pore complex mediates nucleocytoplasmic traffic ranging from a single histone to a viral genome. To date, dissecting mechanism has been more an exercise in prediction than biochemical certainty. A recent study combines recombinant proteins with nuclei reconstituted in vitro to test predictions in a startlingly productive manner.

MeSH terms

  • Active Transport, Cell Nucleus*
  • Animals
  • Humans
  • Nuclear Pore / metabolism*
  • Nuclear Pore Complex Proteins / metabolism*

Substances

  • Nuclear Pore Complex Proteins