Abstract
Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Adolescent
-
Behavioral Symptoms / etiology
-
Behavioral Symptoms / genetics
-
Brain / blood supply
-
Brain / pathology*
-
Cognitive Behavioral Therapy / methods
-
DNA Mutational Analysis
-
Female
-
Humans
-
Image Processing, Computer-Assisted
-
Magnetic Resonance Imaging
-
Male
-
Marijuana Abuse* / complications
-
Marijuana Abuse* / genetics
-
Marijuana Abuse* / pathology
-
Marijuana Abuse* / rehabilitation
-
Oxygen / blood
-
Polymorphism, Genetic / genetics*
-
Receptors, Serotonin / genetics*
-
Serotonin Plasma Membrane Transport Proteins / genetics*
Substances
-
Receptors, Serotonin
-
Serotonin Plasma Membrane Transport Proteins
-
Oxygen