A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

Psychiatry Res. 2012 Nov 30;204(2-3):112-6. doi: 10.1016/j.pscychresns.2012.10.011.

Abstract

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Behavioral Symptoms / etiology
  • Behavioral Symptoms / genetics
  • Brain / blood supply
  • Brain / pathology*
  • Cognitive Behavioral Therapy / methods
  • DNA Mutational Analysis
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Marijuana Abuse* / complications
  • Marijuana Abuse* / genetics
  • Marijuana Abuse* / pathology
  • Marijuana Abuse* / rehabilitation
  • Oxygen / blood
  • Polymorphism, Genetic / genetics*
  • Receptors, Serotonin / genetics*
  • Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

  • Receptors, Serotonin
  • Serotonin Plasma Membrane Transport Proteins
  • Oxygen