Spread of different rhinovirus B genotypes in hospitalized children in Spain

Influenza Other Respir Viruses. 2013 Sep;7(5):623-8. doi: 10.1111/irv.12061. Epub 2012 Dec 6.

Abstract

Human Rhinovirus (HRV) classification is an evolving process. New genotypes have been described within HRV-A and HRV-C species, but only one has been accepted related to HRV-B. From 2003 to 2010, a total of 3987 nasopharyngeal aspirate samples were taken from pediatric patients admitted to the Severo Ochoa Hospital in Madrid (Spain). After viral analysis, 949 (23.8%) tested positive to HRV. A random selection of 397 (42%) positive samples showed that 39 (9.8%) were HRV-B. The sequencing of partial VP4/VP2 coding region revealed the spread of 13 of 25 defined HRV-B serotypes and three putative new genotypes. Such results remark the high diversity of HRV-B.

Keywords: Genotype; human rhinovirus; pediatric patients; respiratory infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Hospitalized
  • Child, Preschool
  • Female
  • Genotype
  • Humans
  • Infant
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Picornaviridae Infections / epidemiology
  • Picornaviridae Infections / virology*
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / virology*
  • Rhinovirus / classification
  • Rhinovirus / genetics*
  • Rhinovirus / isolation & purification*
  • Spain