Abstract
Four new benzofuran derivatives, ribisin A (1), ribisin B (2), ribisin C (3), and ribisin D (4), were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures including their absolute configurations were determined by NMR and CD exciton chirality methods. Compounds 1-4 were found to promote neurite outgrowth in NGF-mediated PC12 cells at concentrations ranging from 1 to 30 μM. The structure-activity relationships of these compounds are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Basidiomycota / chemistry*
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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China
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Fruiting Bodies, Fungal / chemistry
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Molecular Structure
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Nerve Growth Factors / chemistry
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Nerve Growth Factors / isolation & purification*
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Nerve Growth Factors / pharmacology*
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Neurites / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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PC12 Cells / drug effects
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Rats
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Structure-Activity Relationship
Substances
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Benzofurans
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Nerve Growth Factors