Many employees return home with fever with or without other accompanying symptoms. Fever can be a manifestation of a minor, self-limited process or can herald a progressive, life-threatening illness. The assessment of this group is often hampered by the clinician's lack of familiarity with the types of infections that the patient may have encountered while traveling. The evaluation of such patients should focus on: What infections are possible given where the patient has lived or traveled and the time when exposures may have occurred? Which of these infections is more probable given the patient's clinical findings and potential exposures? Which of these infections is treatable or transmissible or both? On the other hand, the outbreak of plague at the Libyan-Egyptian borders and the high density rodents and their ecto-parasitic fleas in many Egyptian governorates should be embarked a control program to rodents and fleas and to raise the awareness of the concerned authorizes.