Objective: To prepare positive-ionized liposome gel containing paeonol and study its stability and cutaneous permeation kinetics in vitro.
Methods: Prepared the liposome gel by dispersion-ultrasonic and gridding method, and studied the stability with the impact factor experiments. Compared the permeation rate of liposome gel with conventional gel in vitro using the Franz-diffusion cell.
Results: Mean diameter of the liposome was (132.7 +/- 14.1) nm with Zeta potential of (+33.54 +/- 1.95) mV and mean entrapment efficiency of (73.04 +/- 1.24)% (n=3), and the content of paeonol was (3.17 +/- 0.13) mg/g (n=3). The liposome gel had a promising appearance. It was stable at the humidity and the room temperature while was sensitive at the light and the temperature from 40 degrees C to 60 degrees C. The cumulative penetration amounts of the liposome gel was higher than that of the conventional gel (P < 0.05). Its cutaneous penetration rate and cumulative amounts in skin were higher than those of the conventional gel (P < 0.05).
Conclusion: The positive-ionized liposome gel containing paeonol is stable and feasibly prepared. It can enhance the cutaneous permeation efficiency and guarantee the persistent release rate.