Secondary metabolites from the roots of Beilschmiedia tsangii and their anti-inflammatory activities

Int J Mol Sci. 2012 Dec 3;13(12):16430-43. doi: 10.3390/ijms131216430.

Abstract

Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8-11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1-7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC(50) value of 31.70 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / metabolism
  • Anti-Inflammatory Agents / pharmacology
  • Carboxylic Acids / chemistry
  • Carboxylic Acids / isolation & purification
  • Carboxylic Acids / pharmacology
  • Inhibitory Concentration 50
  • Lauraceae / chemistry*
  • Lauraceae / metabolism
  • Lignans / chemistry
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Nitric Oxide Synthase Type II / antagonists & inhibitors
  • Plant Roots / chemistry*
  • Plant Roots / metabolism
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Carboxylic Acids
  • Lignans
  • Sesquiterpenes
  • endiandric acid
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II