Abstract
Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8-11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1-7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC(50) value of 31.70 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / metabolism
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Anti-Inflammatory Agents / pharmacology
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Carboxylic Acids / chemistry
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Carboxylic Acids / isolation & purification
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Carboxylic Acids / pharmacology
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Inhibitory Concentration 50
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Lauraceae / chemistry*
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Lauraceae / metabolism
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology
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Nitric Oxide Synthase Type II / antagonists & inhibitors
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Plant Roots / chemistry*
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Plant Roots / metabolism
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Anti-Inflammatory Agents
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Carboxylic Acids
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Lignans
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Sesquiterpenes
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endiandric acid
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NOS2 protein, human
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Nitric Oxide Synthase Type II