Photodegradable polyesters for triggered release

Int J Mol Sci. 2012 Dec 3;13(12):16387-99. doi: 10.3390/ijms131216387.

Abstract

Photodegradable polyesters were synthesized with a photolabile monomer 2-nitrophenylethylene glycol and dioyl chlorides with different lengths. These polymers can be assembled to form polymeric particles with encapsulation of target substances. Light activation can degrade these particles and release payloads in both aqueous solutions and RAW 264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biodegradable Plastics / chemistry
  • Cells, Cultured
  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / pharmacokinetics
  • Drug Carriers / chemistry*
  • Drug Carriers / radiation effects*
  • Drug Delivery Systems
  • Materials Testing
  • Mice
  • Nanoparticles* / chemistry
  • Nanoparticles* / radiation effects
  • Oxazines / administration & dosage
  • Oxazines / pharmacokinetics
  • Photolysis*
  • Polyesters / chemistry*
  • Polyesters / radiation effects
  • Polymers / chemistry
  • Polymers / radiation effects
  • Ultraviolet Rays

Substances

  • Biodegradable Plastics
  • Delayed-Action Preparations
  • Drug Carriers
  • Oxazines
  • Polyesters
  • Polymers
  • nile red