Triterpene saponins from Clethra barbinervis and their hyaluronidase inhibitory activities

Toshihiro Murata; Atsushi Suzuki; Nagisa Mafune; Eriko Sato; Toshio Miyase; Fumihiko Yoshizaki

doi:10.1248/cpb.c12-00566

Triterpene saponins from Clethra barbinervis and their hyaluronidase inhibitory activities

Chem Pharm Bull (Tokyo). 2013;61(2):134-43. doi: 10.1248/cpb.c12-00566. Epub 2012 Dec 3.

Authors

Toshihiro Murata¹, Atsushi Suzuki, Nagisa Mafune, Eriko Sato, Toshio Miyase, Fumihiko Yoshizaki

Affiliation

¹ Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Sendai 981-8558, Japan. murata-t@tohoku-pharm.ac.jp

PMID: 23207679
DOI: 10.1248/cpb.c12-00566

Abstract

An extract of Clethra barbinervis with an inhibitory effect on hyaluronidase activity was fractionated guided by the results of an assay. From the active fractions, seven new triterpene saponins (1-4, 6-8) and a new lignan glycoside (14) were isolated together with 14 known compounds (5, 9-13, 15-22). Some of the saponins (2, 3, 9) were revealed as hyaluronidase inhibitors similar to epicatechin (17).

MeSH terms

Clethraceae / chemistry*
Hyaluronoglucosaminidase / antagonists & inhibitors*
Hyaluronoglucosaminidase / metabolism
Magnetic Resonance Spectroscopy
Molecular Conformation
Protein Binding
Saponins / chemistry*
Saponins / isolation & purification
Saponins / metabolism
Triterpenes / chemistry*
Triterpenes / isolation & purification
Triterpenes / metabolism

Substances

Saponins
Triterpenes
Hyaluronoglucosaminidase