Abstract
Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Breast Neoplasms / drug therapy
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Disease Progression
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Female
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Gene Expression Regulation, Neoplastic / drug effects
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Genetic Predisposition to Disease
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Humans
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Molecular Targeted Therapy
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Polymorphism, Genetic*
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Polymorphism, Single Nucleotide
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Risk
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
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Vascular Endothelial Growth Factors / genetics*
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Vascular Endothelial Growth Factors / metabolism
Substances
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors