Five new diterpenoids from an Okinawan soft coral, Cespitularia sp

Mar Drugs. 2012 Nov 30;10(12):2741-8. doi: 10.3390/md10122741.

Abstract

Five new diterpenoids 1-5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC₅₀ 5.85 μM), while these new diterpenoids 1-5 were much less active (IC₅₀ 28.2-91.4 μM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / pathology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • HCT116 Cells
  • Humans
  • Inhibitory Concentration 50
  • Japan
  • Spectrum Analysis

Substances

  • Diterpenes