Abstract
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
Keywords:
apoptosis mechanisms; carcinogenesis.; chemoprevention; hepatic cancer; quercetin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticarcinogenic Agents / pharmacology
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Carcinogenesis / drug effects
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Caspases / metabolism
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Chemoprevention / methods
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Liver / chemistry
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Liver / drug effects
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Liver / pathology
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Liver Neoplasms, Experimental / chemistry
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Liver Neoplasms, Experimental / metabolism
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Liver Neoplasms, Experimental / pathology*
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Liver Neoplasms, Experimental / prevention & control*
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Male
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Oxidative Stress / drug effects
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Precancerous Conditions / chemistry
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Precancerous Conditions / drug therapy*
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Precancerous Conditions / metabolism
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Precancerous Conditions / pathology
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Quercetin / pharmacology*
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Rats
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Rats, Inbred F344
Substances
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Anticarcinogenic Agents
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Antineoplastic Agents
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Quercetin
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Caspases