Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part I: The essential oil

U Pongprayoon; P Soontornsaratune; S Jarikasem; T Sematong; S Wasuwat; P Claeson

doi:10.1016/S0944-7113(97)80003-7

Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part I: The essential oil

Phytomedicine. 1997 Feb;3(4):319-22. doi: 10.1016/S0944-7113(97)80003-7.

Authors

U Pongprayoon¹, P Soontornsaratune, S Jarikasem, T Sematong, S Wasuwat, P Claeson

Affiliation

¹ Pharmaceuticals and Natural Products Department, Thailand Institute of Scientific and Technological Research, Chatuchak, Bangkok, Thailand.

PMID: 23195188
DOI: 10.1016/S0944-7113(97)80003-7

Abstract

The essential oil of the rhizome of Zingiber cassumunar was found to exhibit a topical antiinflammatory effect, when tested using the model of carrageenan-induced hind paw edema in rats (ID(50) = 22 mg oil/paw). Individual assessment of topical antiinflammatory activity of the five major components of the oil demonstrated that (E)-1-(3,4-dimethoxyphenyl)butadiene (DMPBD), terpinen-4-ol and α-terpinene significantly inhibited edema formation, whereas sabinene and γ-terpinene were inactive up to 6 mg/paw. The most active compound, DMPBD, was found to be an antiinflammatory agent twice as potent as the reference drug diclofenac (ID(50) = 3 vs 6 mg/paw, respectively).