Chronic renal failure complications and management in kidney transplanted and nontransplanted patients

Transplant Proc. 2012 Dec;44(10):2997-3000. doi: 10.1016/j.transproceed.2012.05.084.

Abstract

Background: Our purpose was to compare the management of chronic kidney disease (CKD) according to Kidney Disease Quality Initiative (K/DOQI) recommendations in kidney transplanted patients (T) and nontransplanted ones (NT).

Methods: Data concerning CKD complications were collected retrospectively. Patients seen in consultations in our department from May 2009 to June 2010 were selected if they had at least 6 months of follow-up, CKD stage 4 or 5, and no exclusion criteria namely hospitalization, active cancer, or infection in the 3 months before data collection.

Results: Fifty-eight T were compared with 85 NT matched by CKD stage (4-5). Anemia within K/DOQI target was better controlled among NT (51.2% versus 41.3%); however, ferritin levels within K/DOQI target were higher (80% T versus 51.7% NT). Average arterial blood pressure was similar in both groups but 51.7% of T were in K/DOQI target versus 41% of NT. Dyslipidemia within cholesterol K/DOQI target was better controlled in 60% (NT) versus 35% NT with 63.5% versus 38% NT within low-density lipoprotein K/DOQI targets. Phosphorus level was better controlled among T; parathyroid was better controlled in among 65% NT versus 50% T within the target level.

Conclusion: Most complications of CKD were better managed among NT.

Publication types

  • Comparative Study

MeSH terms

  • Anemia / blood
  • Anemia / etiology
  • Anemia / therapy
  • Biomarkers / blood
  • Blood Pressure
  • Chi-Square Distribution
  • Dyslipidemias / blood
  • Dyslipidemias / etiology
  • Dyslipidemias / therapy
  • Ferritins / blood
  • Guideline Adherence
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Hypertension / therapy
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery
  • Kidney Failure, Chronic / therapy*
  • Kidney Transplantation* / adverse effects
  • Kidney Transplantation* / standards
  • Lipids / blood
  • Outcome and Process Assessment, Health Care* / standards
  • Parathyroid Hormone / blood
  • Phosphorus / blood
  • Practice Guidelines as Topic
  • Renal Dialysis* / adverse effects
  • Renal Dialysis* / standards
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Biomarkers
  • Lipids
  • PTH protein, human
  • Parathyroid Hormone
  • Phosphorus
  • Ferritins