Inhibitory effects of the lichen metabolite lobaric acid on arachidonate metabolism in vitro

K Ingolfsdottir; S R Gissurarson; B Müller-Jakic; W Breu; H Wagner

doi:10.1016/S0944-7113(96)80049-3

Inhibitory effects of the lichen metabolite lobaric acid on arachidonate metabolism in vitro

Phytomedicine. 1996 Jan;2(3):243-6. doi: 10.1016/S0944-7113(96)80049-3.

Authors

K Ingolfsdottir¹, S R Gissurarson, B Müller-Jakic, W Breu, H Wagner

Affiliation

¹ Dept. of Pharmacy, University of Iceland, Hagi/Hofsvallagata, IS-107 Reykjavik, Iceland.

PMID: 23194623
DOI: 10.1016/S0944-7113(96)80049-3

Abstract

An extract containing phenolic constituents of the lichen Stereocaulon alpinum was shown to exhibit potent in vitro inhibitory effects on arachidonate 5-lipoxygenase from porcine leucocytes. The active component has been identified as the orcinol depsidone lobaric acid (1), which shows dose-dependent inhibitory effects on the enzyme, with an IC(50) value of 7.3 μM. Lobaric acid exhibits approximately 4-fold in vitro selectivity for 5-lipoxygenase as compared to cyclooxygenase.